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KMID : 0376219870240010011
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Chonnam Medical Journal
1987 Volume.24 No. 1 p.11 ~ p.20
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Effect of salts on the bactericidal action of penicillin
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Abstract
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The author has investigated the effect of salts on the bactericidal action of penicillin(PC). For this experiments, the staphylococcus aureus and various salts were used. The following results were obtained.
The bactericidal action of PC was inhibited by the monovalent and divalent salts as well as some concentrations of trivalent salt.
The bactericidal action of PC was a little more inhibited by the complex of monovalent and divalent salts than each salt alone.
The PC action was inhibited by salt even though the reaction system is kept at 370C for 24 hours.
The PC action-inhibiting degree of salt was much reduced when the bacteria, against the 24 hours-cultured bacteria under static condition, cultured for 3 hours under aeration are used.
The salt did not give any influence to the PC action at 4°C against 370C.
If the PC is pretreated with salt at 370C for 30 minutes, the bactericidal activity of PC was not changed. However, the PC action was much reduced if the bacteria are pretreated with salt for the same time.
The action mechanism of salt was mainly discussed.
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KEYWORD
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